Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease
Identifieur interne : 000157 ( Main/Exploration ); précédent : 000156; suivant : 000158Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease
Auteurs : Johanna C. Scheuermann [États-Unis] ; Laurie A. Boyer [États-Unis]Source :
- The EMBO Journal [ 0261-4189 ] ; 2013-07-03.
English descriptors
- Teeft :
- Aberrant expression, Additional lncrnas, Anril, Antisense, Antisense transcript, Antisense transcription, Antisense transcripts, Biol, Biology organization, Boyer, Bruneau, Bvht, Cardiac, Cardiac biology, Cardiac development, Cardiac disease, Cardiac hypertrophy, Cardiac lineage, Cardiogenesis, Cardiomyocyte differentiation, Cardiovascular, Cardiovascular development, Cell biol, Chang, Chromatin, Congenital, Congenital heart disease, Derrien, Drosophila, Drosophila heart, Drosophila heart development, Duplex, Embo, Embo journal, Epigenetic regulation, Eukaryote, Expression patterns, Fendrr, Gene, Gene expression, Genet, Genome, Genomic, Genomic sites, Guttman, Gwas, Heart development, Human genome, Ink4 locus, Intergenic, Klattenhoff, Lateral plate mesoderm, Lincrnas, Lineage, Lncrna, Lncrna function, Lncrna transcripts, Lncrnas, Locus, Long noncoding, Long noncoding rnas, Long rnas, Lower eukaryotes, Mammal, Mammalian heart development, Many cases, Mesoderm, Mesp1, Mrna, Mutation, Myh6, Myh7, Myocardial infarction, Nats, Noncoding, Opposite strand, Pathological conditions, Prc2, Proc natl acad, Progenitor, Promoter, Receptor, Regulator, Rinn, Rna, Scheuermann, Sequence conservation, Small rnas, Srivastava, Steroid receptor, Therapeutic intervention, Transcript, Transcription, Transcription factors, Transcriptional, Transcriptional programs, Ulitsky, Wang.
Abstract
Cardiogenesis in mammals requires exquisite control of gene expression and faulty regulation of transcriptional programs underpins congenital heart disease (CHD), the most common defect among live births. Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.
This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.
Url:
DOI: 10.1038/emboj.2013.134
Affiliations:
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Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.</div><div type="abstract">This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Scheuermann, Johanna C" sort="Scheuermann, Johanna C" uniqKey="Scheuermann J" first="Johanna C" last="Scheuermann">Johanna C. Scheuermann</name></noRegion><name sortKey="Boyer, Laurie A" sort="Boyer, Laurie A" uniqKey="Boyer L" first="Laurie A" last="Boyer">Laurie A. Boyer</name><name sortKey="Boyer, Laurie A" sort="Boyer, Laurie A" uniqKey="Boyer L" first="Laurie A" last="Boyer">Laurie A. Boyer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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